For a complete list of publications from NCBI, please click here.
2017
Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ.
Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y, Yuan HX, Guan KL.
Cancer Res. (2017). pii: canres.3229.2016L2hgdh deficiency accumulates L-2-hydroxyglutarate with progressive leukoencephalopathy and neurodegeneration.
Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qui Z, Ye D, Guan KL.
Mol Cell Biol. (2017). pii: MCB.00492-16MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.
Ma X, Zhang S, He L, Rong Y, Brier LW, Sun Q, Liu R, Fan W, Chen S, Yue Z, Kim J, Guan KL, Li D, Zhong Q.
Autophagy. (2017). 6:1-16NLK mediates the osmotic stress signal to phosphorylate and activate YAP.
Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan KL.
EMBO Rep. (2017). 18, 72-86A YAP-IL6ST auto regulatory loop activated on APC loss controls colonic tumorigenesis.
Taniguchi K, Moroishi T, de Jong PR, Krawczyk, Grebbin BM, Luo H, Xu R, Glob-Schwarz N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon E, Raz E, Farin HF, Guan KL, Hayback J, Datz C, Zhang K, Karin M.
PNAS. (2017). 114, 1644-8
2016
KDM2B targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.
Han X, Zha Z, Yuan H, Feng X, Xio YK, Lei Q, Guan KL, Xiong Y.
Oncogene. (2016). 35, 4179-90Hypertension-associated C825T polymorphism impairs the function of Gb3 to target GRK2 ubiquitination.
Zha Z, Han XR, Smith MD, Lei QY, Guan KL, Xiong Y.
Cell Discovery. (2016). 2, 16005A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9 mediated genetic screening.
Diao Y, Li B, Meng Z, Jung I, Lee AY, Dixon J. Maliskova L, Guan KL, Shen Y, Ren B.
Genome Res. (2016). 26, 397-405SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense.
Zou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, guan KL, Yang P, Yu H, Ye D.
EMBO Rep. (2016). 17, 811-22MST1 shuts off cytosolic antiviral defense through IRF3 phosphorylation.
Meng F, Zhou R, Wu S, Zhang Q, Jin Q, Zhou Y, Plouffe SW, Liu S, Song H, Xia Z, Zhao B, Yu S, Feng XH, Guan KL, Zou J, Xu P.
Genes and Dev. (2016). 30, 1086-1100Thromboxane A2 activates YAP/TAZ to induce vascular smooth cell proliferation and migration.
Feng X, Liu P, Zhou X, i MT, Li FL, Wang Z, Meng ZP, Sun YP, Yu Y, Xiong Y, Yuan HX, Guan KL.
J. Biol. Chem. (2016). 291, 18947-58Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis.
Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan KL, Li YS, Chien S.
PNAS. (2016). 113, 11525-30Acetylation destabilizes fatty acid synthase to inhibit de novo lipogenesis and tumor cell growth.
Lin HP, Cheng ZL, He RY, Song L, Tian MX, Zhou LS, Groh BS, Liu WR, i MB, Ding C, Shi YH, Guan KL, Yu D, Xiong Y.
Cancer Res. (2016). in pressCharacterization of Hippo pathway components by gene inactivation.
Plouffe SW, Meng Z, Lin KC, Hong AW, Chun JV, Guan KL.
Mol. Cell. (2016). 64, 993-08The Hippo pathway kinases LATS1/2 suppress cancer immunity.
Moroishi T, Hayashi T, Pan W, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL.
Cell. (2016). 167, 1525-39Mechanisms of the Hippo pathway regulation.
Meng Z, Moroishi T, Guan KL.
Genes and Dev. (2016). 30, 1-17The Hippo pathway in intestinal regeneration and disease.
Hong AW, Meng Z, Guan KL.
Nat. Rev. Gastroenterol. and Hepatol. (2016). 13, 324-37Structural insights of mTOR complex 1.
Yuan HX, Guan KL.
Cell Research. (2016). 26, 267-8Guidelines for the use and interpretation of assays for monitoring autophagy.
Klionsky DJ, et al.
Autophagy. (2016). 12, 1-222Glycoholics anonymous: Cancer sobers up with mTORC1
Fu V, Moroishi T, Guan KL.
Cancer Cell. (2016). 29, 432-434
2015
2-Hydroxyglutate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth.
Ma S, Jiang B, Deng W, Gu ZK, Wu FZ, Li T, Xia Y, Yang H, Ye D, Xiong Y, Guan KL.
Oncotarget. (2015). 6, 8606-20Estrogen regulates Hippo signaling via GPER in breast cancer.
Zhou X, Wang S, Wang Z, Feng X, Liu P, Lv X, Li F, Yu FX, Sun Y, Yuan H, Zhu H, Xiong Y, Lei QY, Guan KL.
J. Clin. Invest. (2015). 125, 2123-35A non-canonical function of Gb as a subunit of E3 ligase in targeting GRK2 ubiquitylation.
Zha Z, Han X, Smith MD, Liu Y, Giguere PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan KL, Lei QYY, Xiong Y.
Mol. Cell. (2015). 58, 794-803Netrin-1 exerts oncogenic activities through enhancing YAP stability.
Qi Q, Li DY, Luo HR, Guan KL, Ye K.
Proc. Natrl. Acad. Sci. (2015). 112, 7255-60PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction.
Lv X, Liu CY, Wang Z, Sun YP, Xiong Y, Lei QY, Guan KL.
EMBO Rep. (2015). 16, 975-85Opposing roles of conventional and novel PKC in the Hippo-YAP pathway regulation.
Gong R, Yu FX, Hong AW, Plouffe SW, Zhao B, Liu G, Xu Y, Guan KL.
Cell Res. (2015). 25, 985-8Regulation of PGK1 acetylation by insulin and mTOR pathway modulates glycolytic ATP production and cellular redox potential.
Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang YP, Chen X, Lin H, Zhou L, Chen L, Yang C, Xiong Y, Ye D, Guan KL.
PLOS Biology. (2015). 13, e1002243MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway.
Meng Z, Moroishi T, Mottier-Pavie V, Plouffe SW, Hansen CG, Hong AW, Park HW, Mo JS, Lu W, Lu S, Flores F, Yu FX, Halder G, Guan KL.
Nature Commun. (2015). 6, 8357Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signaling.
Nemazanyy I, Montagnac G, Russell RC, Morzyglod L, Burnol AF, Guan KL, Pende M, Panasyuk G.
Nature Commun. (2015). 6, 8283Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming.
Ma T, Li J, Xu Y, Yu C, Xu T, Wang H, Liu K, Cao N, Nie BM, Zhu S, Xu S, Li K, Wei WG, Guan KL, Ding S.
Nature Cell Biol. (20105). 17, 1379-87Oncometabolite D-2-hydroxyglutarate inhibits ALKBH DNA repair enzymes and sensitizes IDH-mutated cells to alkylating agents.
Wang P, Wu J, Ma S, Zhang L, Yao J, Hoadley KA, Wilderson MD, Perou CM, Guan KL, Ye D, Xiong Y.
Cell Rep. (2015). 13, 2353-61NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.
Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan KL.
Genes and Dev. (2015). 29, 2362-76The Hippo pathway effector YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1.
Hansen CG, Ng YLD, Lam WM, Plouffe SW, Guan KL.
Cell Res. (2015). 25, 1299-313Hippo pathway in regulation of gastrointestinal tissues.
Yu F, Meng Z, Plouffe S, Guan KL.
Ann. Rev. Physiol. (2015). 77, 201-27The Hippo pathway in human cancer.
Moroishi T, Hansen C, Guan KL.
Nature Rev. Cancer. (2015). 15, 73-9The Hippo pathway in heart development, regeneration, and diseases.
Zhou Q, Li L, Zhao B, Guan KL.
Circulation Res. (2015). 116, 1431-1447YAP and TAZ: a nexus for Hippo signaling and beyond.
Hansen C, Moroishi T, Guan KL.
Trends in Cell Bio. (2015). 25, 499-513AMPK and autophagy in glucose/glycogen metabolism.
Ha J, Guan KL, Kim J.
Mol. Aspects Med. (2015). 46, 46-62Hippo pathway in organ size control, tissue homeostasis, and cancer.
Yu FX, Zhao B, Guan KL.
Cell. (2015). 163, 811-828YAP as oncotarget in uveal melanoma.
Yu FX, Zhang K, Guan KL.
Oncoscience. (2015). 1, 480-1Glutathione-S-transferase (GST)-fusion assays for studying for protein-protein interactions.
Vikis HG, Guan KL.
Methods Mol. Biol. (2015). 1278, 353-64The Sin1 PH domain connects mTORC2 to PI3K.
Yuan HX, Guan KL.
Cancer Discovery. (2015). 5, 1127-9
Alternative Wnt Signaling Activates YAP/TAZ.
Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu F, Alexander CM, Wang C, Guan KL.
Cell. (2015). in pressA YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu F, Karin M, Pan D, Guan KL.
Genes Dev. (2015). in pressSIRT3-dependent GOT2 acetylation enhances the malate-aspartate NADH shuttle activity to promote pancreatic tumor growth.
Yang H, Zhou L, Zhao Y, Sun Y, Zhang J, Wang Y, Guan KL, Xiong Y, Ye D.
EMBO J. (2015). 34, 1110-25A gp130-Src-YAP Module links intestinal injury and inflammation to epithelial regeneration.
Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M.
Nature. (2015). 519, 57-62WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation.
Wang Y, Xiao M, Chen X, Xu Y, Chen L, Wang P, Yang H, Ma S, Jiang B, Ye D, Guan KL, Xiong Y.
Mol. Cell. (2015). 57, 1-12Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway.
Liu G, Yu FX, Kim YC, Meng Z, Naipauer J, Looney DJ, Lu X, Gutkind JS, Mesri EA, Guan KL.
Oncogene. (2015). 34,3536-46YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression.
Gao, Zhang Y, Han X, Li F, Wang X, Wang R, Fang Z, Tong X, Yao S, Li F, Feng Y, Sun Y, Hou Y, Yang Z, Guan KL, Chen H, Zhang L, Ji H.
Nature Comm. (2015). 5, 4629The Hippo Pathway in Heart Development, Regeneration, and Diseases.
Zhou Q, Li L, Zhao B, Guan KL.
Circ Res. (2015). 116(8):1431-1447Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH.
Sci Rep. (2015). 5:9502Glutathione-S-Transferase (GST)-Fusion Based Assays for Studying Protein-Protein Interactions.
Vikis HG, Guan KL.
Methods Mol Biol. (2015). 1278:353-64Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
Mo JS, Meng Z, Kim YC, Park HW, Hansen CG, Kim S, Lim DS, Guan KL.
Nat Cell Biol. (2015). 17(4):500-10Disease implications of the Hippo/YAP pathway.
Plouffe SW, Hong AW, Guan KL.
Trends Mol Med. (2015). 21(4):212-222Micro(RNA) managing by mTORC1.
Jewell JL, Flores F, Guan KL.
Mol Cell. (2015). 57(4):575-6mTOR: a pharmacologic target for autophagy regulation.
Kim YC, Guan KL.
J Clin Invest. (2015). 125(1):25-32Differential regulation of mTORC1 by leucine and glutamine.
Jewell JL, Kim YC, Russell RC, Yu F, Park HW, Plouffe SW, Tagliabracci VS, Guan KL.
Science. (2015). pii: 1259472
2014
Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal
Li T, Liu M, Feng X, Wang Z, Das I, Xu Y, Zhou X, Sun Y, Guan KL, Xiong Y, Lei QY.
J. Biol. Chem. (2014). 289, 3775-85mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases.
Tang H, Inoki K, Lee M, Wright M, Khuong A, Sugiarto A, Garner M, Oaik J, Dpinho R, Goldman R, Guan KL, Shrager JB.
Science Signaling. (2014). 7, ra18, 1-10Both Decreased and Increased SRPK1 Levels Promote Cancer by Interfering with PHLPP-Mediated Dephosphorylation of Akt.
Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng Z, Newton AC, Sun P, Zhou H, Fu XD.
Mol. Cell. (2014). in pressMutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.
Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Bastian BC, Zhang K, Guan KL.
Cancer Cell. (2014). in pressRag GTPases are cardioprotective by regulating lysosomal function
Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan KL.
Nature Comm. (2014).Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase.
Xu Y, Li F, Li T, Zhou X, Deng C, Guan KL, Lei, QY, Xiong Y.
Cancer Research. (2014). in pressRegulation of G6PD acetylation by KAT9/SIRT2 modulates NADPH homeostatis and cell survival during oxidative stress.
Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D.
EMBO J. (2014). in pressTranscription and processing: multilayer controls of RNA biogenesis by the Hippo pathway,
Yu F, Guan KL.
EMBO J. (2014). in press
2013
ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase
Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL.
Nat Cell Biol. (2013). 15(7): 10.1038/ncb2757Regulation of the Hippo pathway and implications for anticancer drug development.
Park HW, Guan KL.
Trends Pharmacol Sci. (2013). S0165-6147(13) 155-7Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease
Nemazanny I, Blaauw B, Paolini C, Caillaud C, Protasi F, Mueller A, Proikas-Cezanne T, Russel RC, Guan KL, Nishino I, Sandri M, Pende M, Panasyuk G.
EMBO Mol Med. (2013). 5(6): 870-890LDH-A Acetylation: Implication in Cancer
Zhao D, Xiong Y, Lei QY, Guan KL.
Oncotarget. (2013). 4(6): 802-803Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer
Zhao D, Zou SW, Liu Y, Zhou X, Mo Y, Wang P, Xu YH, Dong B, Xiong Y, Lei QY, Guan KL.
Cancer Cell. (2013). 23(4):10.1016Nutrient Signaling to mTOR and Cell Growth
Jewell JL, Guan KL.
Trends Biochem Sci. (2013). 38(5): 233-242Amino acid signalling upstream of mTOR
Jewell JL, Russell RC, Guan KL.
Nat Rev Mol Cell Biol. (2013). 14(3): 133-139Microtubule-associated Protein/Microtubule Affinity-regulating Kinase 4 (MARK4) Is a Negative Regulator of the Mammalian Target of Rapamycin Complex 1 (mTORC1)
Li L, Guan KL.
J Biol Chem. (2013). 288(1): 703-708Tumor development is associated with dramatic decreases of TET gene expression and global 5-hydroxymethylcytosine.
Yang H, Liu Y, Bai F, Zhang JY, Ma SH, Liu J, Xu Z, Zhu HG, Ling ZQ, Ye D, Guan KL, Xiong Y.
Oncogene. (2013). 32, 663-669Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas.
Wang P, Dong Q, et al… Ye D, Guan KL, Xiong Y, Qin LX, Chiang DY.
Oncogene. (2013). in pressDifferential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy.
Kim J, Kim YC, Fang C, Russell RC, Kim JH, Fan W, Liu R, Zhong Q, Guan KL.
Cell. (2013). 152, 290-303Regulation of PIK3C3/VPS34 complexes by mTOR in nutrient stress-induced autophagy.
Yuan HX, Russell R, Guan KL.
Autophagy. (2013). 12, 1983-95Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation.
Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Pan DJ, Taylor SS, Lai ZC, Guan KL.
Genes & Dev. (2013). 27, 1223-32Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.
Lin R, Xue RT, Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY.
Mol. Cell. (2013). 51, 506-518Mitogenic and oncogenic signals stimulate K433 acetylation to promote PKM2 protein kinase activity and nuclear localization.
Lv L, Xu Y, Zhao D, Li F, Wang W, Sasaki N, Jiang Y, Zhou X, Li T, Guan KL, Lei Q, Xiong Y.
Mol. Cell. (2013). 52, 340-352Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration and angiogenesis.
Dai X, She P, Chi F, Feng Y, Liu H, Jin D, Zhao Y, Guo X, Jiang D, Guan KL, Zhong TP, Zhao B.
J. Biol. Chem. (2013). 288, 34041-51LATS2 suppressed oncogenic Wnt signaling by disrupting b-catenin/BCL9 interaction.
Li J, Chen X, Ding X, Cheng Y, Zhao B, Lai ZC, Al Hezaimi K, Hakem R, Guan KL, Wang CY.
Cell Rep. (2013). 5, 1650-63
2012
Upstream regulators of the Hippo pathway
Yu FX, Mo JS, Guan KL.
Cell Cycle. (2012). 11(22): 4097–4098IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives
Yang H, Ye D, Guan KL, Xiong Y.
Clin Cancer Res. (2012). 18(20): 5562–5571Regulation of the Hippo–YAP pathway by protease-activated receptors(PARs)
Mo JS, Yu FX, Gong R, Brown JH, Guan KL.
Genes Dev. (2012). 26(19): 2138–2143YAP mediates crosstalk between the Hippo and PI3K-TOR pathways by suppressing PTEN via miR-29.
Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo F, Guan KL.
Nature Cell Biol. (2012). 14, 1322-1329Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression
Magee JA, Ikenoue T, Nakada D, Lee JY, Guan KL, Morrison SJ.
Cell Stem Cell. (2012). 11(3): 415–428The YAP and TAZ transcription coactivators: key downstream effectors of the mammalian Hippo pathway
Hong W, Guan KL.
Semin Cell Dev Biol. (2012). 23(7): 785–793Regulation of the Hippo-YAP pathway by G-protein coupled receptor signaling
Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL.
Cell. (2012). 150(4): 780–791A Critical Role for Rictor in T-lymphopoiesis
Tang F, Wu Q, Ikenoue T, Guan KL, Liu Y, Zheng P.
J Immunol. (2012). 189(4): 1850–1857Down Syndrome Cell Adhesion Molecule (DSCAM) Associates with Uncoordinated-5C (UNC5C) in Netrin-1-mediated Growth Cone Collapse
Purohit AA, Li W, Qu C, Dwyer T, Shao Q, Guan KL, Liu G.
J Biol Chem. (2012). 287(32): 27126–27138The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCF?-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition
Huang W, Lv X, Liu CY, Zha A, Zhang H, Jiang Y, Xiong Y, Lei QY, Guan KL.
J Biol Chem. (2012). 287(31): 26245–26253Mechanistic insights into the regulation of metabolic enzymes by acetylation
Xiong Y, Guan KL.
J Cell Biol. (2012). 198(2): 155–164Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan KL.
Genes Dev. (2012). 26(12): 1326–1338The mechanisms of IDH mutations in tumorigenesis
Ye D, Xiong Y, Guan KL.
Cell Res. (2012). 22(7): 1102–1104Alterations of Metabolic Genes and Metabolites in Cancer
Oermann EK, Wu J, Guan KL, Xiong Y.
Semin Cell Dev Biol. (2012). 23(4): 370–380Organ Size Control by Hippo and TOR Pathways
Tumaneng K, Russell RC, Guan KL.
Curr Biol. (2012). 22(9): R368–R379The Vam6 and Gtr1–Gtr2 pathway activates TORC1 in response to amino acids in fission yeast
Valbuena N, Guan KL, Moreno S.
J Cell Sci. (2012). 125(8): 1920–1928Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky DJ, et al.
Autophagy. (2012). 8(4): 445–544Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1
Zhang T, Wang S, Lin Y, Xu W, Ye D, Xiong Y, Zhao S, Guan KL.
Cell Metab. (2012). 15(1): 75–87Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
Zhao B, Li L, Wang L, Wang CY, Yu J, Guan KL.
Genes Dev. (2012). 26(1): 54–68
2011
The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
Kang YJ, Lu MK, Guan KL.
Cell Death & Differentiation. (2011). 18, 133-44Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.
Zhao B, Li L, Lu O, Wang LH, Liu C, Lei Q, Guan KL.
Genes & Dev. (2011). 25, 51-63Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenases.
Xu W, Yang H, Liu Y, et al… Guan KL, Zhao S, Xiong Y.
Cancer Cell. (2011). 19, 17-30PP1 Cooperates with ASPP2 to dephosphorylate and activate TAZ.
Liu C, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei Q, Guan KL.
J. Biol. Chem. (2011). 286, 5558-66AMPK and mTOR regulate autophagy via direct phosphorylation of ULK1.
Kim J, Kundu M, Viollet B, Guan KL.
Nature Cell Biol. (2011). 13, 132-141Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction.
Hallows WC, Yu W, Smith BC, Devires MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM.
Mol. Cell. (2011). 41, 139-49mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy.
Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg RA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL.
J. Clin. Invest. (2011). 121, 181-196Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.
Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J.
Nature Cell Biol. (2011). 13, 263-272IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL.
Proc. Natl. Acad. Sci. (2011). 108, 6474-9Tumor suppressor SIRT3 deacetylates and activates manganese superoxide dismutase (SOD2) to scavenge ROS.
Chen Y, Zhang J, Lin Y, Lei Q, Guan KL, Zhao S, Xiong Y.
EMBO Report. (2011). 12, 534-41Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.
Jiang W, Wang S, Xiao M, Lin Y, Lei QY, Xiong Y, Guan KL, Zhao S.
Mol. Cell. (2011). 43, 33-44Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth.
Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Xu Y, Li Z, Wang G, Huang Y, Zhao S, Xiong Y, Guan KL, Lei QY.
Mol. Cell. (2011). 42, 719-30The Tuberous Sclerosis Complex-Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells.
Wu Q, Liu Y, Chen C, Ikenoue T, Qiao Y, Li CS, Li W, Guan KL, Liu Y, Zheng P.
J. Immunol. (2011). 187, 1106-12Crystal Structure of Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.
Gong R, Li L, Liu Y, Wang P, Yang H, Wang L, Cheng J, Guan KL, Xu Y.
Genes & Dev. (2011). 25, 1668-73Redox regulates mTORC1 activity by modulating the TSC1/TSC2-Rheb GTPase pathway.
Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K.
J. Biol. Chem. (2011). 286, 32651-60Regulation of intermediate metabolism by protein acetylation.
Guan KL, Xiong Y.
TIBS. (2011). 36, 108-116Amino acid signaling in mTOR activation.
Kim J, Guan KL.
Ann. Rev. Biochem. (2011). 80, 1001-32The Hippo tumor suppressor pathway in organ size control, tissue regeneration and stem cell self-renewal.
Zhao B, Tumaneng K, Guan KL.
Nature Cell Biol. (2011). 13, 877-83An emerging role for TOR signaling in mammalian tissue and stem cell physiology.
Russell RC, Fang C, Guan KL.
Development. (2011). 138, 3343-56AMPK and mTOR in cellular energy homeostasis and drug targets.
Inoki K, Kim J, Guan KL.
Ann. Rev. Pharmacol. Toxicol. (2011). 52, 381-400
2010
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).
Zhao B, Li L, Wang CY, Guan KL.
Genes & Dev. (2010). 24, 72-85Wnt/GSK3 signaling regulates ATF4 and its implication in canonical Wnt signaling-induced osteogenesis.
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J. Biol. Chem. (2003). 278, 13663-13671Insulin Signaling Inhibits the 5-HT2C Receptor in Choroid Plexus via MAP kinase.
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Sugimoto T, Haneda M, Togawa M, Isono M, Shikano T, Araki SI, Nakahiko T, Kashiwagi S, Guan KL, Kikkawa R.
J. Biol. Chem. (1996). 271, 544-547Selective activation of MEK-1 but not MEK-2 by A-raf from epidermal growth factor stimulated Hela cells.
Wu X, Noh S, Zhou G, Dixon JE, Guan KL.
J. Biol. Chem. (1996). 271, 3265-3271Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and EMK2.
Butch E, Guan KL.
J. Biol. Chem. (1996). 4230-4235Contributions of the mitogen-activated protein (MAP) kinase backbone and phosphorylation loop to MEK specificity.:
Robinson MJ, Cheng M, Khokhlatchev A, Ebert D, Ahn N, Guan KL, Stein B, Goldsmith E, Cobb MH.
J. Biol Chem. (1996). 271, 29734-29739Regulation and function of the mitogen activated protein kinase (MAPK) signal transduction pathway.
Wang Y, Guan KL.
Bio/Pharma Quaterly. (1996). 1(4), 23-26
1995
Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen activated protein kinase.
Guan KL, Butch E.
J. Biol. Chem. (1995). 270, 7197-7203Nerve growth factor stimulates a novel protein kinase in PC-12 cells that phosphorylates and activates MEK.
Pang R, Zheng CF, Guan KL, Saltiel AR.
Biochem. J. (1995). 307, 513-519Characterization of MEK1 phosphorylation by v-Mos protein.
Pham CD, Arlinghaus RB, Zheng CF, Guan KL, Singh B.
Oncogene (1995). 10, 1683-1688Mek-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other development events.
Wu Y, Han M, Guan KL.
Genes & Dev. (1995). 9, 742-755The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
Kornfeld K, Guan KL, Horvitz HR.
Genes & Dev. (1995). 9, 756-768Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini.
Rui D, Zheng CF, Guan KL, Williams JA.
Am. J. Physiol. (1995). 268, G1060-1065Phosphorylation and activation of the ATP-Mg-Dependent Protein Phosphatase by the Mitogen Activated Protein Kinase.
Wang QM, Guan KL, Roach PJ, Depaoli-Roach AA.
J. Biol. Chem. (1995). 270, 18352-18358Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from fission yeast S. pombe.
Zhang ZY, Zhou G, Denu JM, Wu L, Tang X, Mondesert O, Russell P, Butch E, Guan KL.
Biochemistry. (1995). 34, 10560-10568Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans.
Church DL, Guan KL, Lambie EJ.
Development. (1995). 121, 2525-2535Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex.
Waters SB, Holt KH, Ross SE, Syu LJ, Guan KL, Saltiel AR, Koretzky GA, Pessin JE.
J. Biol. Chem. (1995). 270, 20883-20886
1994
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.
Zheng CF, Guan KL.
The EMBO J. (1994). 13, 1123-1131Growth factor induced MEK activation is primarily mediated by an activator different from c-raf.
Zheng CF, Ohmichi M, Saltiel AR, Guan KL.
Biochemistry. (1994). 33, 5595-5599Cytoplasmic localization of the mitogen activated protein kinase activator, MEK.
Zheng CF, Guan, KL.
J. Biol. Chem. (1994). 269, 19947-19952
Simian virus 40 small T antigen cooperates with mitogen activated kinases to stimulate AP-1 activity.
Frost JA, Alberts AS, Sontag E, Guan KL, Mumby MC, Feraminsco JR.
Mol. Cell. Biol. (1994). 14, 6244-6252Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, Matera G, Xiong Y.
Genes & Dev. (1994). 8, 2939-2952
1993
Improved vectors for expression and purification of recombinant proteins.
Dixon JE, Hakes D, Guan KL.
Methods in Genetics. (1993). 2, 44-53
Bacterial and viral protein tyrosine phosphatases.
Guan KL, Dixon JE.
Seminars in Cell Biology. (1993). 4, 389-396A eukaryotic homolog to viral Ser/Thr/Tyr phosphatase.
Guan KL, Hakes D, Park HD, Cooper TG, Dixon JE.
Trends in Biochem. Sci. (1993). 18, 6Cloning and characterization of two distinct human ERK activator kinases, MEK1 and MEK2,
Zheng CF, Guan KL.
J. Biol. Chem. (1993). 268, 11435-11439Dephosphorylation and inactivation of the mitogen activated protein kinases by a mitogen induced protein phosphatase.
Zheng CF, Guan KL.
J. Biol. Chem. (1993). 268, 16116-16119Normal mitochondrial structure and genome maintenance in yeast requires the dynamine like product of the MGM1 gene.
Guan KL, Farh L, Marshall TK, Deschenes RJ.
Current Genetics. (1993). 24, 141-148Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.
Zheng CF, Guan KL.
J. Biol. Chem. (1993). 268, 23933-23939
1992
Isolation and characterization of a second protein tyrosine phosphatase gene, PTP2, from Saccharomyces cerevisiae.
Guan KL, Deschenes RJ, Dixon JE.
J. Biol. Chem. (1992). 267, 10024-10020A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation.
Guan KL, Hakes D, Wang Y, Park HD, Cooper TG, Dixon JE.
Proc. Natl. Acad. Sci. USA. (1992). 89, 12175-12179Negative regulation of mitosis by functionally overlapping PTPases in fission yeast.
Millar JBA, Russell P, Dixon JE, Guan KL.
The EMBO J. (1992). 11, 4943-4952
1991
Evidence for protein tyrosine phosphatase catalysis proceeding Via a cysteine-phosphate intermediate.
Guan KL, Dixon JE.
J. Biol. Chem. (1991). 266, 17026-17030Expression of rat PTP1 in normal and transformed cells.
Woodford TA, Guan KL, Dixon JE.
Adv. Prot. Phosphatases. (1991). 6, 503-524One step purification of eukaryotic proteins expressed in E. coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione-S-transferase.
Guan KL, Dixon JE.
Anal. Biochem. (1991). 192, 262-267Tyrosine phosphate hydrolysis of proteins by an essential Yersiniavirulence determinant.
Bliska JB, Guan KL, Dixon JE, Falkow SA.
Proc. Natl. Acad. Sci. USA (1991). 88, 1187-1191A Tyr/Ser protein phosphatase encoded by vaccinia virus.
Guan KL, Broyles SS, Dixon JE.
Nature. (1991). 350, 359-362Cloning and expression of a yeast protein tyrosine phosphatase.
Guan KL, Deschenes, RJ, Qiu H, Dixon JE.
J. Biol. Chem. (1991). 266, 12964-12970De novo purine nucleotide biosynthesis: cloning and expression of a eukaryotic cDNA encoding 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase.
Ni LY, Guan KL, Zalkin H, Dixon JE.
Gene. (1991). 106, 197-20
1990
Sequence of the precursor of bovine liver mitochondrial aldehyde dehydrogenase as determined from its cDNA and its gene and its functionality.
Guan KL, Weiner H.
Arch. Biophys. Biochem. (1990). 277, 351-360Cloning and expression of a protein-tyrosine-phosphatase.
Guan KL, Haun RS, Watson SJ, Geahlen RL, Dixon JE.
Proc. Natl. Acad. Sci. USA. (1990). 87, 1501-1505Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia.
Guan KL, Dixon JE.
Science. (1990). 249, 553-556
1989
Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenase deduced from cDNA sequences.
Farres J, Guan KL, Weiner H.
Eur. J. Biochem. (1989). 180, 67-74Influence of the 5’-end region of aldehyde dehydrogenase mRNA on translational efficiency: potential secondary structure inhibition of translation in vitro.
Guan, K-L., and Weiner, H. (1989)
J. Biol. Chem. 264, 17764-17769.
1988
Signal peptide sequence of rat liver mitochondrial aldehyde dehydrogenase deduced from cDNA.
Farres J, Guan KL, Weiner H.
Biochem. Biophys. Res. Comm. (1988). 150, 1083-1087Purification and characterization of beef and pig liver aldehyde dehydrogenases.
Guan K., Pak YK, Tu GC, Cao, QN, Weiner H.
Alcoholism: Clin. Exp. Res. (1988). 12, 713-719
1987
Molecular biology studies of beef liver aldehyde dehydrogenase in Enzymology and Molecular Biology of Carbonyl Metabolism: aldehyde dehydrogenase, aldo-keto reductase and alcohol dehydrogenase
Guan KL, Weiner H.
Weiner, H. & Flynn, T.G., eds. (1987). pp. 15-24, Alan R, Liss, Inc., New York.