Toshiro Moroishi

is currently focused on understanding the regulation of the Hippo signaling pathway and YAP/TAZ transcription co-activators in development and tumorigenesis. He obtained his Ph.D. in Medical Science from Kyushu University in Japan. His Ph.D. work focused on understanding the regulation of iron metabolism by ubiquitin-proteasome pathway as well as their implication in human disease.



2002-2008 M.D., Faculty of Medicine, Kyushu University, Fukuoka, Japan
2008-2012 Ph.D. in Medical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
2012-2013 Postdoctoral research in Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan (Laboratory of Dr. Keiichi Nakayama)
2013-present Postdoctoral research fellow in Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, USA (Laboratory of Dr. Kun-Liang Guan)


Selected Publications

The emerging roles of YAP and TAZ in cancer
Moroishi, T., Hansen, C.G. & Guan, K.L .
Nat. Rev. Cancer 15, 73-9 (2015).

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.
Moroishi, T. et al.
Genes Dev. 29, 1271-84 (2015).

HERC2 Targets the Iron Regulator FBXL5 for Degradation and Modulates Iron Metabolism.
Moroishi, T., Yamauchi, T., Nishiyama, M. & Nakayama, K.I
J. Biol. Chem. 289, 16430-16441 (2014).

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.

Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. & Nakayama, K.I.
Cell Metab. 14, 339-51 (2011).

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Moroishi, T., Hayashi, T., Pan, W.W., Fujita, Y., Holt, M.V., Qin, J., Carson, D.A., and Guan, K.L.
Cell 167, 1525-39 (2016).