Toshiro Moroishi
is currently focused on understanding the regulation of the Hippo signaling pathway and YAP/TAZ transcription co-activators in development and tumorigenesis. He obtained his Ph.D. in Medical Science from Kyushu University in Japan. His Ph.D. work focused on understanding the regulation of iron metabolism by ubiquitin-proteasome pathway as well as their implication in human disease.
Education
| 2002-2008 | M.D., Faculty of Medicine, Kyushu University, Fukuoka, Japan |
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| 2008-2012 | Ph.D. in Medical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan |
| 2012-2013 | Postdoctoral research in Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan (Laboratory of Dr. Keiichi Nakayama) |
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| 2013-present | Postdoctoral research fellow in Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, USA (Laboratory of Dr. Kun-Liang Guan) |
Selected Publications
The emerging roles of YAP and TAZ in cancer
Moroishi, T., Hansen, C.G. & Guan, K.L .
Nat. Rev. Cancer 15, 73-9 (2015).A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.
Moroishi, T. et al.
Genes Dev. 29, 1271-84 (2015).HERC2 Targets the Iron Regulator FBXL5 for Degradation and Modulates Iron Metabolism.
Moroishi, T., Yamauchi, T., Nishiyama, M. & Nakayama, K.I
J. Biol. Chem. 289, 16430-16441 (2014).
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. & Nakayama, K.I.
Cell Metab. 14, 339-51 (2011).The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.
Moroishi, T., Hayashi, T., Pan, W.W., Fujita, Y., Holt, M.V., Qin, J., Carson, D.A., and Guan, K.L.
Cell 167, 1525-39 (2016).