Kimberly Lin
is a graduate student studying the regulation of the Hippo signaling pathway and YAP/TAZ transcription co-activators in development and tumorigenesis.
Education
| 2007-2011 | Microbiology, Immunology, and Molecular Genetics, B.S. University of California, Los Angeles, CA |
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| 2014-present | Graduate Student. Department of Biomedical Sciences. University of California San Diego. San Diego, California |
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Selected Publications
FLT3 D835 Mutations Confer Differential Resistance to Type II FLT3 Inhibitors.
Kimberly C. Lin*, Catherine C. Smith*, Adrian Stecula, Andrej Sali, Neil P. Shah.
(accepted, Leukemia).Characterizing and Overriding the Structural Mechanism of the Quizartinib-resistant FLT3 “Gatekeeper” F681L Mutation with PLX3397
Catherine C. Smith, Chao Zhang, Kimberly Lin, Elisabeth Lasater, Ying Zhang, Evan Massi, Lauren E. Damon, Matthew Pendleton, Ali Bashir, Robert Sebra, Alexander Perl, Andrew Kasarskis, Rafe Shellooe, Garson Tsang, Heidi Carias, Ben Powell, Elizabeth A. Burton, Bernice Matusow, Jiazhong Zhang, Wayne Spevak, Prabha N. Ibrahim, Mai H. Le, Henry H. Hsu, Gaston Habets, Brian L. West, Gideon Bollag and Neil P. Shah.
Cancer Discov. 2015 Apr 6. pii: CD-15-0060. [Epub ahead of print]Overcoming Myelosuppression Due to Synthetic Lethal Toxicity in FLT3-Targeted Acute Myeloid Leukemia Therapy.
Alexander Warkentin, Michael Lopez, Elizabeth Lasater, Kimberly Lin, Catherine Smith, Neil Shah, Kevan Shokat.
Elife. 2014 Dec 22;3. doi: 10.7554/eLife.03445.Crenolanib is a selective type I “pan-FLT3” inhibitor.
Catherine C. Smith*, Elisabeth Lasater*, Kimberly Lin, Qi Wang, Whitney Stewart, Lauren E. Damon, Alexander E. Perl, Grace Jeschke, Mayumi Sugita, Martin Carroll, Scott Kogan, John Kuriyan and Neil P. Shah.
PNAS 2014 111 (14) 5319-5324; published ahead of print March 12, 2014Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD.
Catherine Choy Smith, Elisabeth Anne Lasater, Xiaotian Zhu, Kimberly Chen Lin, Whitney Kay Stewart, Lauren Elizabeth Damon, Sara Salerno, and Neil Pravin Shah.
Blood. 2013 Apr 18;121(16):3165-71. doi: 10.1182/blood-2012-07-442871. Epub 2013 Feb 21.The role of B-RAF mutations in melanoma and the induction of EMT via dysregulation of the NF-κB/Snail/RKIP/PTEN circuit.
Kimberly Lin, Stavroula Baritaki, Loredana Militello, Graziella Malaponte, Benjamin Bonavida.
Genes Cancer. 2010 May;1(5):409 420.